(19)
(11) EP 4 073 108 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
18.06.2025 Bulletin 2025/25

(45) Mention of the grant of the patent:
07.05.2025 Bulletin 2025/19

(21) Application number: 20897989.8

(22) Date of filing: 09.12.2020
(51) International Patent Classification (IPC): 
C07K 16/10(2006.01)
A61K 47/69(2017.01)
 C12N 15/82(2006.01)
(52) Cooperative Patent Classification (CPC):
C12N 15/8258; C12N 15/8203; C07K 16/1018; A61K 47/6901
(86) International application number:
PCT/US2020/063902
(87) International publication number:
WO 2021/119062 (17.06.2021 Gazette 2021/24)

(54)

VIRUS AND ANTIGEN PURIFICATION AND CONJUGATION

VIRUS- UND ANTIGENREINIGUNG UND -KONJUGATION

PURIFICATION ET CONJUGAISON DE VIRUS ET D'ANTIGÈNE

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 10.12.2019 US 201916709063

(43) Date of publication of application:
19.10.2022 Bulletin 2022/42

(73) Proprietor: KBio Holdings Limited
London WC2R 3LA (GB)

(72) Inventors:
  • BURDEN, Leigh
    Owensboro, Kentucky 42301 (US)
  • HUME, Steven, D.
    Owensboro, Kentucky 42303 (US)
  • MORTON, Joshua
    Evansville, Indiana 47712 (US)
  • POGUE, Greg
    Austin, Texas 78759 (US)
  • BRATCHER, Barry
    Owensboro, Kentucky 42303 (US)
  • HAYDON, Hugh, A.
    Louisville, Kentucky 40207 (US)
  • SIMPSON, Carrie, A.
    Evansville, Indiana 47715 (US)
  • PARTAIN, Nick
    Owensboro, Kentucky 42301 (US)
  • SHEPHERD, John, W.
    Owensboro, Kentucky 42303 (US)

(74) Representative: D Young & Co LLP 
3 Noble Street
London EC2V 7BQ
London EC2V 7BQ (GB)


(56) References cited: : 
WO-A2-2005/091753
US-A1- 2009 117 144
US-A1- 2021 000 942
 US-A1- 2009 053 261
US-A1- 2020 113 999
   
  • SMITH ET AL: "Assembly of trans-encapsidated recombinant viral vectors engineered from Tobacco mosaic virus and Semliki Forest virus and their evaluation as immunogens", VIROLOGY, ELSEVIER, AMSTERDAM, NL, vol. 358, no. 2, 25 January 2007 (2007-01-25), pages 321 - 333, XP005853984, ISSN: 0042-6822, DOI: 10.1016/J.VIROL.2006.08.040
  • SHUKLA SOURABH ET AL: "Plant viral nanoparticles-based HER2 vaccine: Immune response influenced by differential transport, localization and cellular interactions of particulate carriers", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 121, 27 December 2016 (2016-12-27), pages 15 - 27, XP029890667, ISSN: 0142-9612, DOI: 10.1016/J.BIOMATERIALS.2016.12.030
  • MANSOUR AHD A., BANIK SUKALYANI, SURESH RAGAVAN V., KAUR HARDEEP, MALIK MEENAKSHI, MCCORMICK ALISON A., BAKSHI CHANDRA S.: "An Improved Tobacco Mosaic Virus (TMV)-Conjugated Multiantigen Subunit Vaccine Against Respiratory Tularemia", FRONTIERS IN MICROBIOLOGY, 5 June 2018 (2018-06-05), pages 1 - 21, XP055836859
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).