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(11)

EP 4 077 649 A1

(12)

(43) Date of publication: 26.10.2022 Bulletin 2022/43 (21) Application number: 20902958.6 (22) Date of filing: 16.12.2020

(51) International Patent Classification (IPC):  C12N 9/10(2006.01) C12P 5/00(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/415; C12N 9/0083; C12Y 114/99034; C12N 9/90; C12Y 504/99008; C12N 9/14; C12Y 303/0201; C12N 9/0077; C12Y 114/99; C12N 9/1051; C12Y 204/01017; C12P 19/56; C12P 17/02; C12P 33/00; C12P 19/18; C12P 5/007; C12P 19/26; C12Y 205/01021 (86) International application number: PCT/US2020/065285 (87) International publication number: WO 2021/126960 (24.06.2021 Gazette 2021/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 16.12.2019 US 201962948657 P 08.09.2020 US 202063075631 P 30.09.2020 US 202063085557 P (71) Applicant: Manus Bio Inc. Cambridge, MA 02138 (US)

(72) Inventors: GOETTGE, Michelle, N. Cambridge, MA 02138 (US) PHILIPPE, Ryan, N. Cambridge, MA 02138 (US) KUMARAN, Ajikumar, Parayil Cambridge, MA 02138 (US) SANTOS, Christine, Nicole S. Cambridge, MA 02138 (US) DONALD, Jason, Eric Cambridge, MA 02138 (US) FREI, Christopher Cambridge, MA 02138 (US) LOVE, Aaron Cambridge, MA 02138 (US) CHAMBERS, Kaitlin Cambridge, MA 02138 (US) SAMSON, Joyce Cambridge, MA 02138 (US) TOOMEY, Christopher Cambridge, MA 02138 (US) NIEMINEN, Eric Cambridge, MA 02138 (US) (74) Representative: Grund, Martin  Grund Intellectual Property Group Patentanwälte und Solicitor PartG mbB Steinsdorfstraße 2 80538 München 80538 München (DE)