(19)

(11)

EP 4 081 270 A1

(12)

(43) Date of publication: 02.11.2022 Bulletin 2022/44 (21) Application number: 20904883.4 (22) Date of filing: 24.12.2020

(51) International Patent Classification (IPC):  A61L 27/18(2006.01) A61B 17/12(2006.01) A61F 2/24(2006.01) C08G 18/42(2006.01) (52) Cooperative Patent Classification (CPC): C08L 75/06; C08G 2101/00; A61L 27/48; A61L 2430/20; A61L 33/068; A61L 33/0005; A61F 2/2412; A61F 2/2415; B32B 5/245; B32B 27/40; B32B 2307/706; B32B 2307/54; B32B 27/365; B32B 5/18; B32B 2307/56; B32B 2535/00; B32B 2262/0253; B32B 27/065; B32B 2266/0278; B32B 5/022; B32B 2556/00; B32B 2266/0264; B32B 2262/02; B32B 2250/03   C-Sets: C08L 75/06, C08L 67/04; A61L 27/48, C08L 75/04; A61L 27/48, C08L 67/04; A61L 33/068, C08L 75/04; (86) International application number: PCT/US2020/067002 (87) International publication number: WO 2021/134006 (01.07.2021 Gazette 2021/26)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 26.12.2019 US 201962953768 P 13.02.2020 US 202062976252 P (71) Applicant: The Trustees Of Columbia University In The City Of New York New York, NY 10027 (US)	(72) Inventors: KALFA, David Long Island City New York City, NY 11104 (US) SUN, Mingze Englewood, NJ 07631 (US) (74) Representative: Berggren Oy  P.O. Box 16 Eteläinen Rautatiekatu 10A 00101 Helsinki 00101 Helsinki (FI)