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(11)

EP 4 085 144 A1

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(43) Date of publication: 09.11.2022 Bulletin 2022/45 (21) Application number: 20901671.6 (22) Date of filing: 18.12.2020

(51) International Patent Classification (IPC):  C12N 15/864(2006.01) C12P 19/34(2006.01) A61K 35/76(2015.01) C12N 15/79(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/86; C12N 2750/14143; C12N 2310/141; C12N 2750/14122; C12N 2750/14151; C12N 2830/42; C12N 2830/50; A61P 9/00; A01K 2217/075; A01K 2267/0318; A61K 48/005; A61K 48/0075; C07K 14/47 (86) International application number: PCT/US2020/066167 (87) International publication number: WO 2021/127533 (24.06.2021 Gazette 2021/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 19.12.2019 US 201962950834 P (71) Applicant: The Trustees of The University of Pennsylvania Philadelphia, PA 19104 (US)	(72) Inventors: WILSON, James, M. Philadelphia, PA 19103 (US) HINDERER, Christian New Orleans, LA 70115 (US) MILLER, Nimrod Berwyn, PA 19312 (US) (74) Representative: Pohlman, Sandra M.  df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München 80333 München (DE)