(19)

(11)

EP 4 087 618 A1

(12)

(43) Date of publication: 16.11.2022 Bulletin 2022/46 (21) Application number: 21738525.1 (22) Date of filing: 07.01.2021

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) A61K 39/395(2006.01) A61K 45/00(2006.01) C12N 5/16(2006.01) C12N 5/071(2010.01) A61K 39/00(2006.01) C12N 15/00(2006.01) C07H 21/04(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2875; C07K 2317/622; A61K 39/0011; A61K 2039/5156; C12N 2510/00; A61P 35/00; A61P 25/00; A61P 25/28; C07K 14/7051; C07K 2319/03; A61K 45/06; C12N 2501/515; C12N 2501/599; C12N 5/0646; A61K 35/17; A01K 2267/0331; A01K 2227/105; A01K 2207/12; C07K 16/30 (86) International application number: PCT/US2021/012510 (87) International publication number: WO 2021/142127 (15.07.2021 Gazette 2021/28)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 08.01.2020 US 202062958563 P (71) Applicant: Board of Regents, The University of Texas System Austin, TX 78701 (US)	(72) Inventor: REZVANI, Katy Houston, Texas 77030 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)