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(11)

EP 4 090 682 A1

(12)

(43) Date of publication: 23.11.2022 Bulletin 2022/47 (21) Application number: 21704639.0 (22) Date of filing: 13.01.2021

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61K 39/00(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2803; C07K 2317/526; C07K 2317/53; C07K 2317/55; C07K 2317/92; C07K 2317/24; C07K 2317/33; C07K 2317/90; A61K 2039/505; C07K 2317/71; C07K 2317/75 (86) International application number: PCT/US2021/013200 (87) International publication number: WO 2021/146256 (22.07.2021 Gazette 2021/29)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 13.01.2020 US 202062960663 P 26.08.2020 US 202063070728 P 14.10.2020 US 202063091717 P (71) Applicant: Denali Therapeutics Inc. South San Francisco, California 94080 (US)

(72) Inventors: DENNIS, Mark S. San Francisco, California 94080 (US) GU, Zhenyu San Francisco, California 94080 (US) KARIOLIS, Mihalis S. San Francisco, California 94080 (US) MAHON, Cathal S. San Francisco, California 94080 (US) MONROE, Kathryn M. San Francisco, California 94080 (US) PARK, Joshua I. San Francisco, California 94080 (US) PROROK, Rachel San Francisco, California 94080 (US) SILVERMAN, Adam P. San Francisco, California 94080 (US) VAN LENGERICH, Bettina San Francisco, California 94080 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)