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EP 4 093 425 A1

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(43) Date of publication: 30.11.2022 Bulletin 2022/48 (21) Application number: 21702301.9 (22) Date of filing: 18.01.2021

(51) International Patent Classification (IPC):  A61K 38/18(2006.01) A61P 19/02(2006.01) A61K 47/42(2017.01) A61L 27/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 38/1875; A61K 47/42; A61P 19/02 (86) International application number: PCT/GB2021/050112 (87) International publication number: WO 2021/148779 (29.07.2021 Gazette 2021/30)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 21.01.2020 GB 202000840 (71) Applicants: Cell Guidance Systems Limited Cambridge, Cambridgeshire CB22 3AT (GB) Cambridge Enterprise Limited Cambridge, Cambridgeshire CB2 1TN (GB)

(72) Inventors: JONES, Michael Cambridge Cambridgeshire CB22 3AT (GB) PERNSTICH, Christian Cambridge Cambridgeshire CB22 3AT (GB) WHITTY, Ciara Cambridge Cambridgeshire CB22 3AT (GB) GANDHI, Raj Cambridge Cambridgeshire CB22 3AT (GB) HENSON, Frances Cambridge, Cambridgeshire CB2 1TN (GB) MCCASKIE, Andrew Cambridge, Cambridgeshire CB2 1TN (GB) (74) Representative: Secerna LLP  The Old Fire Station 18 Clifford Street York YO1 9RD York YO1 9RD (GB)