(19)
(11) EP 4 096 646 A1

(12)

(43) Date of publication:
07.12.2022 Bulletin 2022/49

(21) Application number: 21705841.1

(22) Date of filing: 26.01.2021
(51) International Patent Classification (IPC): 
A61K 31/00(2006.01)
A61P 35/00(2006.01)
A61K 31/136(2006.01)
A61K 31/473(2006.01)
A61K 31/555(2006.01)
A61K 31/7068(2006.01)
A61K 45/06(2006.01)
 A61K 39/395(2006.01)
C07K 16/28(2006.01)
A61K 31/337(2006.01)
A61K 31/519(2006.01)
A61K 31/704(2006.01)
A61K 33/243(2019.01)
(52) Cooperative Patent Classification (CPC):
C07K 16/2827; C07K 16/2803; A61K 31/337; A61K 33/243; A61K 45/06; A61K 2039/505; A61K 2039/507; A61K 2039/54; A61K 2039/545; A61P 35/00; C07K 2317/90; A61K 39/395
 
C-Sets:
  1. A61K 39/395, A61K 2300/00;
  2. A61K 31/337, A61K 2300/00;
  3. A61K 33/243, A61K 2300/00;
(86) International application number:
PCT/US2021/015143
(87) International publication number:
WO 2021/154761 (05.08.2021 Gazette 2021/31)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 27.01.2020 US 202062966448 P
05.03.2020 US 202062985822 P
24.03.2020 US 202062994272 P
24.03.2020 WO PCT/US2020/024526
30.07.2020 US 202063059054 P
31.07.2020 US 202063059960 P
04.09.2020 WO PCT/US2020/049415
04.09.2020 US 202063074807 P
04.09.2020 US 202063074827 P
30.09.2020 US 202063085890 P
23.10.2020 US 202063105198 P
16.11.2020 US 202063114517 P
11.12.2020 US 202063124693 P
17.12.2020 US 202063127109 P

(71) Applicants:
  • GENENTECH, INC.
    South San Francisco, CA 94080 (US)
  • F. Hoffmann-La Roche AG
    4070 Basel (CH)

(72) Inventors:
  • LAI, Catherine
    San Francisco, CA 94080-4990 (US)
  • LAU, Janet
    San Francisco, CA 94080-4990 (US)
  • LEE, Anthony Jongha
    San Francisco, CA 94080-4990 (US)
  • LI, Shi
    San Francisco, CA 94080-4990 (US)
  • LIN-LIU, Yvonne Gail
    San Francisco, CA 94080-4990 (US)
  • MATHENY, Christina Jeanne
    San Francisco, CA 94080-4990 (US)
  • MENDUS, Diana
    San Francisco, CA 94080-4990 (US)
  • MENG, Raymond D.
    San Francisco, CA 94080-4990 (US)
  • NGUYEN DUC, Anh
    4070 Basel (CH)
  • PATEL, Jilpa Bhupendra
    San Francisco, CA 94080-4990 (US)
  • PHAM, Thinh Quang
    San Francisco, CA 94080-4990 (US)
  • ROONEY, Isabelle Anne
    San Francisco, CA 94080-4990 (US)
  • STEVENS, Heather Blythe
    San Francisco, CA 94080-4990 (US)
  • TROUTMAN, Sarah Marie
    San Francisco, CA 94080-4990 (US)
  • WANG, Lijia
    San Francisco, CA 94080-4990 (US)
  • WANG, Yulei
    San Francisco, CA 94080-4990 (US)
  • WILLIAMS, Patrick Georges Robert
    San Francisco, CA 94080-4990 (US)
  • WU, Benjamin
    San Francisco, CA 94080-4990 (US)
  • YAN, Yibing
    San Francisco, CA 94080-4990 (US)
  • ZHANG, Aijing
    San Francisco, CA 94080-4990 (US)
  • ZHANG, Xiaosong
    San Francisco, CA 94080-4990 (US)
  • BALLINGER, Marcus Dale
    San Francisco, CA 94080-4990 (US)
  • BARAK, Hila
    San Francisco, CA 94080-4990 (US)
  • BENNETT, Elizabeth Alexandra
    San Francisco, CA 94080-4990 (US)
  • CASTRO, Marcela Lucia
    San Francisco, CA 94080-4990 (US)
  • CHA, Edward Namserk
    San Francisco, CA 94080-4990 (US)
  • CHAN, Hui Min Phyllis
    San Francisco, CA 94080-4990 (US)
  • CHUI, Stephen
    San Francisco, CA 94080-4990 United States of America (US)
  • COTTER, Christopher Roland
    San Francisco, CA 94080-4990 United States of America (US)
  • DEGAONKAR, Viraj Vinay
    San Francisco, CA 94080-4990 United States of America (US)
  • GITLITZ, Barbara Jennifer
    San Francisco, CA 94080-4990 United States of America (US)
  • HOANG, Tien
    San Francisco, CA 94080-4990 United States of America (US)
  • KOMATSUBARA, Kimberly Mayumi
    San Francisco, CA 94080-4990 United States of America (US)

(74) Representative: Mewburn Ellis LLP 
Aurora Building Counterslip
Bristol BS1 6BX
Bristol BS1 6BX (GB)

   


(54) METHODS FOR TREATMENT OF CANCER WITH AN ANTI-TIGIT ANTAGONIST ANTIBODY