(19)

(11)

EP 4 096 659 A1

(12)

(43) Date of publication: 07.12.2022 Bulletin 2022/49 (21) Application number: 21748420.3 (22) Date of filing: 26.01.2021

(51) International Patent Classification (IPC):  A61K 31/4427(2006.01) A61P 1/16(2006.01) C07D 409/04(2006.01) A61P 3/06(2006.01) (52) Cooperative Patent Classification (CPC): C07D 409/04; A61P 1/16; A61P 3/06; C07D 491/056 (86) International application number: PCT/US2021/015101 (87) International publication number: WO 2021/154735 (05.08.2021 Gazette 2021/31)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 27.01.2020 US 202062966358 P 24.07.2020 US 202063056410 P (71) Applicant: Capulus Therapeutics, LLC San Francisco CA 94105 (US)	(72) Inventors: GREEN, Michael John Half Moon Bay, California 94019 (US) HART, Barry Patrick San Francisco, California 94105 (US) (74) Representative: Cooley (UK) LLP  22 Bishopsgate London EC2N 4BQ London EC2N 4BQ (GB)