(19)
(11) EP 4 097 093 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
28.02.2024 Bulletin 2024/09

(45) Mention of the grant of the patent:
24.01.2024 Bulletin 2024/04

(21) Application number: 21706792.5

(22) Date of filing: 28.01.2021
(51) International Patent Classification (IPC): 
C07D 401/04(2006.01)
A61P 35/00(2006.01)
 A61K 31/454(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 401/04; A61P 35/00
(86) International application number:
PCT/US2021/015352
(87) International publication number:
WO 2021/154901 (05.08.2021 Gazette 2021/31)

(54)

PROCESSES FOR THE PREPARATION OF GLASDEGIB AND SALT THEREOF AND SOLID STATE FORMS OF GLASDEGIB MALEATE AND PROCESS FOR PREPARATION THEREOF

VERFAHREN ZUR HERSTELLUNG VON GLASDEGIB UND SALZ DAVON SOWIE FESTE FORMEN VON GLASDEGIB-MALEAT UND VERFAHREN ZU SEINER HERSTELLUNG

PROCÉDÉS DE PRÉPARATION DE GLASDEGIB ET DE SEL DE CELUI-CI ET FORMES À L'ÉTAT SOLIDE DE MALÉATE DE GLASDEGIB ET PROCÉDÉ DE PRÉPARATION ASSOCIÉ

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 28.01.2020 IN 202011003718
11.03.2020 IN 202011010330
26.06.2020 IN 202011027219

(43) Date of publication of application:
07.12.2022 Bulletin 2022/49

(60) Divisional application:
23216686.8 / 4327881

(73) Proprietor: Assia Chemical Industries LTD
Tel Aviv 6944020 (IL)

(72) Inventors:
  • MUTHUSAMY, Anantha Rajmohan
    Sivakasi, Tamilnadu 626189 (IN)
  • SINGH, Amit
    Noida, Uttar Pradesh 201310 (IN)
  • CHEMATE, Rajendra Popat
    Ahmednagar, Maharashtra 414304 (IN)
  • PATIL, Bhatu Tumba
    Maharashtra 425432 (IN)
  • REDDY, Elluru Subbi
    Noida, Uttar Pradesh 201308 (IN)
  • LUTHRA, Parven Kumar
    New Delhi 110059 (IN)
  • VASOYA, Sanjay Lakhabhai
    Rajkot, Gujarat 360002 (IN)
  • NIGHOT, Dnyaneshwar Kondibhau
    Pune, Maharashtra 410503 (IN)

(74) Representative: D Young & Co LLP 
120 Holborn
London EC1N 2DY
London EC1N 2DY (GB)


(56) References cited: : 
US-A- 5 925 762
 US-A1- 2018 086 731
   
  • MINO R CAIRA ED - MONTCHAMP JEAN-LUC: "CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS", TOPICS IN CURRENT CHEMISTRY; [TOPICS IN CURRENT CHEMISTRY], SPRINGER, BERLIN, DE, vol. 198, 1 January 1998 (1998-01-01), pages 163-208, XP001156954, ISSN: 0340-1022, DOI: 10.1007/3-540-69178-2_5 [retrieved on 1999-02-26]
  • MICHAEL J. MUNCHHOF ET AL: "Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened", ACS MEDICINAL CHEMISTRY LETTERS, vol. 3, no. 2, 9 February 2012 (2012-02-09), pages 106-111, XP055207149, ISSN: 1948-5875, DOI: 10.1021/ml2002423
  • PENG ZHIHUI ET AL: "Development of a Concise, Asymmetric Synthesis of a Smoothened Receptor (SMO) Inhibitor: Enzymatic Transamination of a 4-Piperidinone with Dynamic Kinetic Resolution", ORGANIC LETTERS ., vol. 16, no. 3, 22 January 2014 (2014-01-22), pages 860-863, XP55810930, US ISSN: 1523-7060, DOI: 10.1021/ol403630g
  • MAGDALENA LITWINOWICZ ET AL: "Carbamoylation of primary, secondary and aromatic amines by dimethyl carbonate in a flow system over solid catalysts", SUSTAINABLE CHEMICAL PROCESSES, BIOMED CENTRAL LTD, LONDON, UK, vol. 3, no. 1, 30 January 2015 (2015-01-30), pages 1-7, XP021213483, ISSN: 2043-7129, DOI: 10.1186/S40508-015-0027-4
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).