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EP 4 097 460 A1

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(43) Date of publication: 07.12.2022 Bulletin 2022/49 (21) Application number: 21702260.7 (22) Date of filing: 27.01.2021

(51) International Patent Classification (IPC):  G01N 27/28(2006.01) G01N 27/416(2006.01) G01N 27/07(2006.01) G01N 27/333(2006.01) G01N 33/02(2006.01) (52) Cooperative Patent Classification (CPC): G01N 27/333; G01N 27/286; G01N 33/02; G01N 27/07 (86) International application number: PCT/EP2021/051859 (87) International publication number: WO 2021/151943 (05.08.2021 Gazette 2021/31)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 28.01.2020 GB 202001177 (71) Applicant: University of The West of England, Bristol Bristol BS16 1QY (GB)

(72) Inventors: DORAN, Olena BRISTOLFRENCHAY CAMPUSY CAMPUS COLDHARBOUR LANE BRISTOL BS16 1QY (GB) CREW, Adrian BRISTOL FRENCHAY CAMPUS COLDHARBOUR LANE BRISTOL BS16 1QY (GB) HART, John P BRISTOL FRENCHAY CAMPUS COLDHARBOUR LANE BRISTOL BS16 1QY (GB) WESTMACOTT, Kelly BRISTOL FRENCHAY CAMPUS COLDHARBOUR LANE BRISTOL BS16 1QY (GB) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)