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(11)

EP 4 100 074 A1

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(43) Date of publication: 14.12.2022 Bulletin 2022/50 (21) Application number: 20917632.0 (22) Date of filing: 06.02.2020

(51) International Patent Classification (IPC):  A61L 27/56(2006.01) A61L 27/54(2006.01) A61F 2/30(2006.01) A61L 27/46(2006.01) A61F 2/28(2006.01) A61L 24/00(2006.01) (52) Cooperative Patent Classification (CPC): A61L 27/46; A61L 27/56; A61L 27/54; A61F 2/28; A61L 27/50; A61L 27/58; A61L 2400/06; A61L 2400/12; A61L 27/34; A61L 24/0084; A61L 24/0036; A61L 24/0042; A61L 24/0015; A61L 2300/406; A61L 2300/414; A61F 2/3094; A61F 2002/2835; A61F 2002/30971   C-Sets: A61L 24/0084, C08L 75/04; A61L 27/46, C08L 75/04; A61L 27/34, C08L 67/04; A61L 27/34, C08L 5/08; A61L 27/34, C08L 89/06; (86) International application number: PCT/US2020/016932 (87) International publication number: WO 2021/158222 (12.08.2021 Gazette 2021/32)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (71) Applicant: Board of Trustees of the University of Arkansas Little Rock, AR 72207 (US)	(72) Inventors: BIRIS, Alexandru S. Little Rock, Arkansas 72207 (US) ALGHAZALI, Karrer M. Little Rock, Arkansas 72211 (US) MHANNAWEE, Anwer Dheyaa Mahdi Little Rock, Arkansas 72204 (US) (74) Representative: Dey, Michael  Weickmann & Weickmann Patent- und Rechtsanwälte PartmbB Postfach 860 820 81635 München 81635 München (DE)