(19)

(11)

EP 4 100 514 A2

(12)

(88) Date of publication A3: 16.09.2021 (43) Date of publication: 14.12.2022 Bulletin 2022/50 (21) Application number: 21750239.2 (22) Date of filing: 02.02.2021

(51) International Patent Classification (IPC):  C12N 5/10(2006.01) C12N 15/863(2006.01) C12N 15/86(2006.01) C12Q 1/68(2018.01) (52) Cooperative Patent Classification (CPC): C12N 2710/24143; A61K 2039/5256; A61K 2039/70; C12N 2710/16134; C12N 2770/20034; A61K 39/001151; C12N 15/86; Y02A 50/30 (86) International application number: PCT/US2021/016247 (87) International publication number: WO 2021/158565 (12.08.2021 Gazette 2021/32)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 03.02.2020 US 202062969628 P 13.11.2020 US 202063113803 P (71) Applicant: City of Hope Duarte, CA 91010-3000 (US)	(72) Inventors: DIAMOND, Don, J. Glendora, CA 91741 (US) WUSSOW, Felix Glendora, CA 91741 (US) (74) Representative: HGF  HGF Limited 1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)