(19)
(11) EP 4 100 530 A1

(12)

(43) Date of publication:
14.12.2022 Bulletin 2022/50

(21) Application number: 21784308.5

(22) Date of filing: 07.04.2021
(51) International Patent Classification (IPC): 
C12N 15/113(2010.01)
 A61P 35/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 35/00; C12N 2310/14; C12N 2310/11; C12N 15/1135; C12N 2320/31; C12N 2310/315; C12N 2310/3231; C12N 2310/341
 
C-Sets:
  1. C12N 2310/321, C12N 2310/3521;
  2. C12N 2310/322, C12N 2310/3533;
  3. C12N 2310/321, C12N 2310/3525;
(86) International application number:
PCT/US2021/026147
(87) International publication number:
WO 2021/207339 (14.10.2021 Gazette 2021/41)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 07.04.2020 US 202016842404

(71) Applicant: The University of North Carolina at Chapel Hill
Chapel Hill, North Carolina 27516 (US)

(72) Inventors:
  • PECOT, Chad
    Pittsboro, North Carolina 27312 (US)
  • AZAM, Salma H.
    Cary, North Carolina 27519 (US)

(74) Representative: Appleyard Lees IP LLP 
15 Clare Road
Halifax HX1 2HY
Halifax HX1 2HY (GB)

   


(54) METHODS AND COMPOSITIONS USING RNA INTERFERENCE AND ANTISENSE OLIGONUCLEOTIDES FOR INHIBITION OF KRAS