(19)

(11)

EP 4 103 208 A1

(12)

(43) Date of publication: 21.12.2022 Bulletin 2022/51 (21) Application number: 21754580.5 (22) Date of filing: 12.02.2021

(51) International Patent Classification (IPC):  A61K 35/74(2015.01) A61K 39/39(2006.01) A61K 39/04(2006.01) C12N 15/70(2006.01) (52) Cooperative Patent Classification (CPC): A61K 35/74; A61K 39/04; C12N 15/70; A61K 39/39; C12N 15/74; A61K 2039/523; A61K 2039/55594; A61K 2039/54; A61P 35/00 (86) International application number: PCT/US2021/018007 (87) International publication number: WO 2021/163602 (19.08.2021 Gazette 2021/33)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 13.02.2020 US 202016790161 (71) Applicant: The Johns Hopkins University Baltimore, Maryland 21218 (US)	(72) Inventors: BISHAI, William, R. Baltimore, Maryland 21231 (US) BIVALACQUA, Trinity, J. Baltimore, Maryland 21210 (US) SINGH, Alok Baltimore, Maryland 21231 (US) PRAHARAJ, Monali Baltimore, Maryland 21231 (US) YOSHIDA, Takahiro Baltimore, Maryland 21218 (US) (74) Representative: Murgitroyd & Company  Murgitroyd House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)