(19)

(11)

EP 4 103 253 A1

(12)

(43) Date of publication: 21.12.2022 Bulletin 2022/51 (21) Application number: 21754150.7 (22) Date of filing: 09.02.2021

(51) International Patent Classification (IPC):  A61M 5/32(2006.01) A61M 5/178(2006.01) A61B 17/34(2006.01) (52) Cooperative Patent Classification (CPC): A61M 5/3291; A61M 5/427; A61M 5/46 (86) International application number: PCT/US2021/017160 (87) International publication number: WO 2021/163005 (19.08.2021 Gazette 2021/33)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 11.02.2020 US 202062972669 P (71) Applicant: Merck Sharp & Dohme LLC Rahway, New Jersey 07065 (US)

(72) Inventors: BROWN, Scott Rahway, New Jersey 07065-0907 (US) CLINE, John, B. Rahway, New Jersey 07065-0907 (US) GALLUPPI, Michael Rahway, New Jersey 07065-0907 (US) GIVAND, Jeffrey, C. Rahway, New Jersey 07065-0907 (US) HU, Guangli Rahway, New Jersey 07065-0907 (US) PERSAK, Steven Carl Rahway, New Jersey 07065-0907 (US) RASHEED, Wail Rahway, New Jersey 07065-0907 (US) (74) Representative: Merck Sharp & Dohme LLC  120 Moorgate London EC2M 6UR London EC2M 6UR (GB)