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EP 4 103 542 A1

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(43) Date of publication: 21.12.2022 Bulletin 2022/51 (21) Application number: 21738179.7 (22) Date of filing: 06.01.2021

(51) International Patent Classification (IPC):  C07C 219/04(2006.01) C07C 219/22(2006.01) C07C 271/20(2006.01) C07C 229/12(2006.01) C07D 207/09(2006.01) C07D 205/04(2006.01) C07D 241/04(2006.01) C07D 451/06(2006.01) (52) Cooperative Patent Classification (CPC): C07D 205/04; C07D 207/09; C07D 211/34; C07D 401/04; A61K 9/5123; C07C 219/04; C07C 229/10; C07C 219/22; C07C 271/20; C07D 319/06; C07D 295/15; C07D 211/22; C07D 207/08; C07D 207/16; C07D 207/14; C07D 211/62; C07D 211/58; C07D 213/36; C07D 295/088; C07D 295/096; C07D 295/13; C07D 455/02; C07D 243/08; C07D 241/04; C07D 451/06 (86) International application number: PCT/US2021/012282 (87) International publication number: WO 2021/141969 (15.07.2021 Gazette 2021/28)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 09.01.2020 US 202062958876 P (71) Applicant: Guide Therapeutics, LLC Cambridge, Massachusetts 02142 (US)

(72) Inventors: HAMILTON, Gregory Lawrence Cambridge, Massachusetts 02142 (US) PATWARDHAN, Neeraj Narendra Cambridge, Massachusetts 02142 (US) SAGO, Cory Dane Cambridge, Massachusetts 02142 (US) SHEHATA, Mina Fawzy Gaballa Cambridge, Massachusetts 02142 (US) CHHABRA, Milloni Balwantkumar Cambridge, Massachusetts 02142 (US) (74) Representative: Forresters IP LLP  Skygarden Erika-Mann-Straße 11 80636 München 80636 München (DE)