(19)
(11) EP 4 103 552 A1

(12)

(43) Date of publication:
21.12.2022 Bulletin 2022/51

(21) Application number: 20728576.8

(22) Date of filing: 12.02.2020
(51) International Patent Classification (IPC): 
C07D 209/40(2006.01)
C07C 337/08(2006.01)
A61P 37/06(2006.01)
A61P 3/10(2006.01)
A61P 25/28(2006.01)
 C07D 209/38(2006.01)
A61K 31/404(2006.01)
A61P 9/10(2006.01)
A61P 19/02(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 209/40; C07D 209/38; A61K 31/404; A61P 37/06; A61P 9/10; A61P 3/10; A61P 19/02; A61P 25/28
(86) International application number:
PCT/TR2020/050104
(87) International publication number:
WO 2021/162650 (19.08.2021 Gazette 2021/33)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(71) Applicants:
  • Istanbul Üniversitesi
    34452 Istanbul (TR)
  • KOC Universitesi
    34450 Istanbul (TR)

(72) Inventors:
  • KARALI, Nilgün Lütfiye
    34452 Fatih/Istanbul (TR)
  • SOYLU, Ozge
    34452 Fatih/Istanbul (TR)
  • GUL, Ahmet
    Fatih/Istanbul (TR)
  • ORER, Hakan Sedat
    34450 Istanbul (TR)
  • ERMAN, Burak
    34450 Sariyer/Istanbul (TR)
  • HASANUSTA, Bahar
    34450 Sariyer/Istanbul (TR)
  • ERSOY, Betül
    34450 Sariyer/Istanbul (TR)
  • LACK, Nathan
    34450 Sariyer/Istanbul (TR)

(74) Representative: Mutlu, Aydin 
Invokat Intellectual Property Services Ltd. Kartaltepe Mh. Yildiztepe Sk. No:6-Bakirköy
34145 Istanbul
34145 Istanbul (TR)

   


(54) 5-FLUORO/5-TRIFLUOROMETHOXY-1H-INDOLE-2,3-DIONE 3-(4-PHENYLTHIOSEMICARBAZONE) DERIVATIVES AS INTERLEUKIN 1 (IL-1) ANTAGONISTS AND ANTI-PYRETIC AND/OR ANTI-INFLAMMATORY AGENTS FOR USE IN TREATING E.G. BEHÇET'S DISEASE