<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE ep-patent-document PUBLIC "-//EPO//EP PATENT DOCUMENT 1.5.1//EN" "ep-patent-document-v1-5-1.dtd">
<ep-patent-document id="EP20728576A1" file="20728576.8" lang="en" country="EP" doc-number="4103552" kind="A1" date-publ="20221221" status="n" dtd-version="ep-patent-document-v1-5-1"><!-- This XML data has been generated under the supervision of the European Patent Office --><SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSKBAHRIS..MTNORSMESMMAKHTNMD..........</B001EP><B003EP>*</B003EP><B005EP>X</B005EP><B007EP>BDM Ver 2.0.16 (1th of February 2022) -  1100000/0</B007EP></eptags></B000><B100><B110>4103552</B110><B130>A1</B130><B140><date>20221221</date></B140><B190>EP</B190></B100><B200><B210>20728576.8</B210><B220><date>20200212</date></B220><B240><B241><date>20220912</date></B241></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B400><B405><date>20221221</date><bnum>202251</bnum></B405><B430><date>20221221</date><bnum>202251</bnum></B430></B400><B500><B510EP><classification-ipcr sequence="1"><text>C07D 209/40        20060101AFI20210820BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>C07D 209/38        20060101ALI20210820BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>C07C 337/08        20060101ALI20210820BHEP        </text></classification-ipcr><classification-ipcr sequence="4"><text>A61K  31/404       20060101ALI20210820BHEP        </text></classification-ipcr><classification-ipcr sequence="5"><text>A61P  37/06        20060101ALI20210820BHEP        </text></classification-ipcr><classification-ipcr sequence="6"><text>A61P   9/10        20060101ALI20210820BHEP        </text></classification-ipcr><classification-ipcr sequence="7"><text>A61P   3/10        20060101ALI20210820BHEP        </text></classification-ipcr><classification-ipcr sequence="8"><text>A61P  19/02        20060101ALI20210820BHEP        </text></classification-ipcr><classification-ipcr sequence="9"><text>A61P  25/28        20060101ALI20210820BHEP        </text></classification-ipcr></B510EP><B520EP><classifications-cpc><classification-cpc sequence="1"><text>C07D 209/40        20130101 FI20200914BHEP        </text></classification-cpc><classification-cpc sequence="2"><text>C07D 209/38        20130101 LI20200914BHEP        </text></classification-cpc><classification-cpc sequence="3"><text>A61K  31/404       20130101 LI20200914BHEP        </text></classification-cpc><classification-cpc sequence="4"><text>A61P  37/06        20180101 LI20200914BHEP        </text></classification-cpc><classification-cpc sequence="5"><text>A61P   9/10        20180101 LI20200914BHEP        </text></classification-cpc><classification-cpc sequence="6"><text>A61P   3/10        20180101 LI20200914BHEP        </text></classification-cpc><classification-cpc sequence="7"><text>A61P  19/02        20180101 LI20200914BHEP        </text></classification-cpc><classification-cpc sequence="8"><text>A61P  25/28        20180101 LI20200914BHEP        </text></classification-cpc></classifications-cpc></B520EP><B540><B541>de</B541><B542>5-FLUOR/5-TRIFLUORMETHOXY-1H-INDOL-2,3-DION 3-(4-PHENYLTHIOSEMICARBAZON) ALS INTERLEUKIN 1 (IL-1) ANTAGONISTEN UND ANTIPYRETISCHE UND/ODER ENTZÜNDUNGSHEMMENDE MITTEL ZUR BEHANDLUNG VON E.B. BEHCUET</B542><B541>en</B541><B542>5-FLUORO/5-TRIFLUOROMETHOXY-1H-INDOLE-2,3-DIONE 3-(4-PHENYLTHIOSEMICARBAZONE) DERIVATIVES AS INTERLEUKIN 1 (IL-1) ANTAGONISTS AND ANTI-PYRETIC AND/OR ANTI-INFLAMMATORY AGENTS FOR USE IN TREATING E.G. BEHÇET'S DISEASE</B542><B541>fr</B541><B542>DÉRIVÉS DE 5-FLUORO/5-TRIFLUOROMÉTHOXY-1H-INDOLE-2,3-DIONE 3-(4-PHÉNYLTHIOSEMICARBAZONE) UTILISÉS EN TANT QU'ANTAGONISTES DE L'INTERLEUKINE 1 (IL-1) ET AGENTS ANTIPYRÉTIQUES ET/OU ANTI-INFLAMMATOIRES DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT, PAR EXEMPLE, DE LA MALADIE DE BEHÇET</B542></B540></B500><B700><B710><B711><snm>Istanbul Üniversitesi</snm><iid>101758603</iid><irf>06-221903-A</irf><adr><str>Beyazit</str><city>34452 Istanbul</city><ctry>TR</ctry></adr></B711><B711><snm>KOC Universitesi</snm><iid>101314021</iid><irf>06-221903-A</irf><adr><str>Rumelifeneri Yolu 
Sariyer</str><city>34450 Istanbul</city><ctry>TR</ctry></adr></B711></B710><B720><B721><snm>KARALI, Nilgün Lütfiye</snm><adr><str>I.U. Eczacilik Fak. Beyazit</str><city>34452 Fatih/Istanbul</city><ctry>TR</ctry></adr></B721><B721><snm>SOYLU, Ozge</snm><adr><str>I.U. Eczacilik Fak. Beyazit</str><city>34452 Fatih/Istanbul</city><ctry>TR</ctry></adr></B721><B721><snm>GUL, Ahmet</snm><adr><str>Istanbul Tip Fak. Capa</str><city>Fatih/Istanbul</city><ctry>TR</ctry></adr></B721><B721><snm>ORER, Hakan Sedat</snm><adr><str>Koc Universitesi Tip Fak. Rumeli Feneri Yolu  
Sariyer</str><city>34450 Istanbul</city><ctry>TR</ctry></adr></B721><B721><snm>ERMAN, Burak</snm><adr><str>Koc Universitesi Müh. Fak. Rumeli Feneri Yolu</str><city>34450 Sariyer/Istanbul</city><ctry>TR</ctry></adr></B721><B721><snm>HASANUSTA, Bahar</snm><adr><str>Koc Universitesi Sa l k B.E. Rumeli Feneri Yolu</str><city>34450 Sariyer/Istanbul</city><ctry>TR</ctry></adr></B721><B721><snm>ERSOY, Betül</snm><adr><str>Koc Universitesi Sa l k B.E. Rumeli Feneri Yolu</str><city>34450 Sariyer/Istanbul</city><ctry>TR</ctry></adr></B721><B721><snm>LACK, Nathan</snm><adr><str>Koc Universitesi Sa l k B.E. Rumeli Feneri Yolu</str><city>34450 Sariyer/Istanbul</city><ctry>TR</ctry></adr></B721></B720><B740><B741><snm>Mutlu, Aydin</snm><iid>101386015</iid><adr><str>Invokat Intellectual Property Services Ltd. 
Kartaltepe Mh. Yildiztepe Sk. 
No:6-Bakirköy</str><city>34145 Istanbul</city><ctry>TR</ctry></adr></B741></B740></B700><B800><B840><ctry>AL</ctry><ctry>AT</ctry><ctry>BE</ctry><ctry>BG</ctry><ctry>CH</ctry><ctry>CY</ctry><ctry>CZ</ctry><ctry>DE</ctry><ctry>DK</ctry><ctry>EE</ctry><ctry>ES</ctry><ctry>FI</ctry><ctry>FR</ctry><ctry>GB</ctry><ctry>GR</ctry><ctry>HR</ctry><ctry>HU</ctry><ctry>IE</ctry><ctry>IS</ctry><ctry>IT</ctry><ctry>LI</ctry><ctry>LT</ctry><ctry>LU</ctry><ctry>LV</ctry><ctry>MC</ctry><ctry>MK</ctry><ctry>MT</ctry><ctry>NL</ctry><ctry>NO</ctry><ctry>PL</ctry><ctry>PT</ctry><ctry>RO</ctry><ctry>RS</ctry><ctry>SE</ctry><ctry>SI</ctry><ctry>SK</ctry><ctry>SM</ctry><ctry>TR</ctry></B840><B844EP><B845EP><ctry>BA</ctry></B845EP><B845EP><ctry>ME</ctry></B845EP></B844EP><B848EP><B849EP><ctry>KH</ctry></B849EP><B849EP><ctry>MA</ctry></B849EP><B849EP><ctry>MD</ctry></B849EP><B849EP><ctry>TN</ctry></B849EP></B848EP><B860><B861><dnum><anum>TR2020050104</anum></dnum><date>20200212</date></B861><B862>en</B862></B860><B870><B871><dnum><pnum>WO2021162650</pnum></dnum><date>20210819</date><bnum>202133</bnum></B871></B870></B800></SDOBI></ep-patent-document>