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(11)

EP 4 103 713 A1

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(43) Date of publication: 21.12.2022 Bulletin 2022/51 (21) Application number: 21780993.8 (22) Date of filing: 12.02.2021

(51) International Patent Classification (IPC):  C12N 15/11(2006.01) A61P 31/16(2006.01) (52) Cooperative Patent Classification (CPC): A61P 31/16; C12N 15/1131; C12N 2310/11; C12N 2310/3231; C12N 2310/341; C12N 2310/113 (86) International application number: PCT/US2021/018025 (87) International publication number: WO 2021/201996 (07.10.2021 Gazette 2021/40)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 14.02.2020 US 202016792103 20.03.2020 US 202062992659 P (71) Applicant: The Board of Trustees of the Leland Stanford Junior University Stanford, CA 94305-2038 (US)

(72) Inventors: GLENN, Jeffrey S. Palo Alto, California 94301 (US) SALUTI, Rachel Hagey Stanford, California 94305 (US) PHAM, Edward A. Palo Alto, California 94306 (US) (74) Representative: Appleyard Lees IP LLP  15 Clare Road Halifax HX1 2HY Halifax HX1 2HY (GB)