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EP 4 103 734 A2

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(88) Date of publication A3: 23.12.2021 (43) Date of publication: 21.12.2022 Bulletin 2022/51 (21) Application number: 21797184.5 (22) Date of filing: 15.02.2021

(51) International Patent Classification (IPC):  C12P 21/02(2006.01) A61K 38/04(2006.01) C07K 7/64(2006.01) C12N 9/10(2006.01) C07K 7/04(2006.01) (52) Cooperative Patent Classification (CPC): C07H 21/02; C07H 1/00; C12N 15/11; C12P 21/02 (86) International application number: PCT/US2021/018134 (87) International publication number: WO 2021/221760 (04.11.2021 Gazette 2021/44)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 14.02.2020 US 202062976672 P 27.03.2020 US 202063001165 P (71) Applicants: Northwestern University Evanston, IL 60208 (US) The Board of Trustees of the University of Illinois Urbana, IL 61801 (US)

(72) Inventors: JEWETT, Michael C. Evanston, IL 60201 (US) LEE, Joongoo Evanston, IL 60201 (US) MOORE, Jeffrey S. Savoy, IL 61874 (US) SCHWARZ, Kevin J. Champaign, IL 61820 (US) (74) Representative: Longland, Emma Louise et al Venner Shipley LLP Byron House Cambridge Business Park Cowley Road Cambridge CB4 0WZ Cambridge CB4 0WZ (GB)