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(11)

EP 4 103 943 A1

(12)

(43) Date of publication: 21.12.2022 Bulletin 2022/51 (21) Application number: 21707901.1 (22) Date of filing: 10.02.2021

(51) International Patent Classification (IPC):  G01N 33/532(2006.01) G01N 33/542(2006.01) G01N 33/74(2006.01) C07K 7/00(2006.01) G01N 33/569(2006.01) G01N 33/94(2006.01) (52) Cooperative Patent Classification (CPC): C07K 7/06; G01N 33/532; G01N 33/542; G01N 33/569; G01N 33/74; G01N 33/94 (86) International application number: PCT/EP2021/053235 (87) International publication number: WO 2021/160688 (19.08.2021 Gazette 2021/33)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 10.02.2020 PT 2020116112 20.02.2020 GB 202002343 (71) Applicant: Instituto de Medicina Molecular João Lobo Antunes 1649-028 Lisboa (PT)	(72) Inventors: GUERRA, Gabriela 4780-137 Santo Tirso (PT) CARVALHO, Patricia 2005-128 Abitureiras (PT) MARTINS, Ivo 1750-409 Lisbon (PT) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)