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EP 4 106 800 A1

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(43) Date of publication: 28.12.2022 Bulletin 2022/52 (21) Application number: 21756853.4 (22) Date of filing: 22.02.2021

(51) International Patent Classification (IPC):  A61K 38/46(2006.01) C12N 15/09(2006.01) C12N 15/55(2006.01) C12N 9/22(2006.01) C12N 15/11(2006.01) (52) Cooperative Patent Classification (CPC): C12N 9/22; C12Y 301/21001; A61K 38/00 (86) International application number: PCT/US2021/019048 (87) International publication number: WO 2021/168413 (26.08.2021 Gazette 2021/34)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 20.02.2020 US 202062978976 P 23.06.2020 US 202063040742 P 12.08.2020 US 202063064566 P (71) Applicant: Neutrolis, Inc. Cambridge, MA 02139 (US)	(72) Inventor: FUCHS, Tobias Cambridge, MA 02139 (US) (74) Representative: Grund, Martin et al Grund Intellectual Property Group Patentanwälte und Solicitor PartG mbB Steinsdorfstraße 2 80538 München 80538 München (DE)