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(11)

EP 4 107 248 A1

(12)

(43) Date of publication: 28.12.2022 Bulletin 2022/52 (21) Application number: 21756467.3 (22) Date of filing: 19.02.2021

(51) International Patent Classification (IPC):  C12M 3/00(2006.01) (52) Cooperative Patent Classification (CPC): C12M 25/14; C12M 25/06; C12M 23/12; C12M 23/20; C12M 31/08 (86) International application number: PCT/SG2021/050082 (87) International publication number: WO 2021/167535 (26.08.2021 Gazette 2021/34)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 20.02.2020 SG 10202001534W (71) Applicant: National University of Singapore Singapore 119077 (SG)

(72) Inventors: BEGHIN ÉP RENIER, Anne Christine Marie Singapore Mechanobiology Institute 21 Lower Kent Ridge Road, Singapore 119077 (SG) GRENCI, Gianluca Singapore Mechanobiology Institute 21 Lower Kent Ridge Road, Singapore 119077 (SG) VIASNOFF, Virgile Nicolas Robert Singapore Mechanobiology Institute 21 Lower Kent Ridge Road, Singapore 119077 (SG) (74) Representative: Baldus, Oliver  Splanemann Rumfordstrasse 7 80469 München 80469 München (DE)