(19)
(11) EP 4 110 796 A1

(12)

(43) Date of publication:
04.01.2023 Bulletin 2023/01

(21) Application number: 20780812.2

(22) Date of filing: 25.06.2020
(51) International Patent Classification (IPC): 
C07K 14/435(2006.01)
C12N 15/62(2006.01)
 A61P 35/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 35/00; C07K 14/435; C07K 2319/00; C07K 2319/21; C07K 2319/50; C07K 2319/70; C12N 15/62; C07K 14/515
(86) International application number:
PCT/US2020/039554
(87) International publication number:
WO 2021/173177 (02.09.2021 Gazette 2021/35)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 28.02.2020 US 202062983328 P
22.05.2020 US 202063029369 P

(71) Applicants:
  • Northwestern University
    Chicago, IL 60614 (US)
  • Mannin Research Inc.
    Toronto, Ontario M4M 1E4 (CA)

(72) Inventors:
  • JIN, Jing
    Chicago, IL 60614 (US)
  • LIU, Pan
    Chicago, IL 60614 (US)
  • RYCZKO, Michael
    Toronto, Ontario M4M 1E4 (CA)

(74) Representative: Regimbeau 
20, rue de Chazelles
75847 Paris Cedex 17
75847 Paris Cedex 17 (FR)

   


(54) CHIMERIC FUSIONS BETWEEN C4-BINDING PROTEIN C-TERMINAL SEGMENT AND ANGIOPOIETIN-1 FIBRINOGEN-LIKE DOMAIN AS ANGIOPOIETIN MIMETICS AND TIE2 AGONISTS TO TREAT VASCULAR DISEASES