(19)
(11) EP 4 114 949 A1

(12)

(43) Date of publication:
11.01.2023 Bulletin 2023/02

(21) Application number: 21714746.1

(22) Date of filing: 05.03.2021
(51) International Patent Classification (IPC): 
C12N 15/113(2010.01)
(52) Cooperative Patent Classification (CPC):
C12N 15/113; C12N 2310/14; C12N 2310/315; C12N 2310/32; C12N 2310/351; C12N 2310/344
 
C-Sets:
  1. C12N 2310/321, C12N 2310/3521;
  2. C12N 2310/322, C12N 2310/3533;
(86) International application number:
PCT/US2021/021049
(87) International publication number:
WO 2021/178778 (10.09.2021 Gazette 2021/36)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 06.03.2020 US 202062985950 P

(71) Applicant: Alnylam Pharmaceuticals, Inc.
Cambridge, MA 02142 (US)

(72) Inventors:
  • CHAN, Amy
    Cambridge, MA 02142 (US)
  • JANAS, Maja
    Cambridge, MA 02142 (US)
  • MCDOUGALL, Robin, D.
    Cambridge, MA 02142 (US)
  • RAMSDEN, Diane
    Cambridge, MA 02142 (US)
  • SCHLEGEL, Mark, K.
    Cambridge, MA 02142 (US)
  • SUTHERLAND, Jessica, E.
    Cambridge, MA 02142 (US)

(74) Representative: Potter Clarkson 
The Belgrave Centre Talbot Street
Nottingham NG1 5GG
Nottingham NG1 5GG (GB)

   


(54) COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF TRANSTHYRETIN (TTR)