(19)

(11)

EP 4 120 887 A1

(12)

(43) Date of publication: 25.01.2023 Bulletin 2023/04 (21) Application number: 21771541.6 (22) Date of filing: 19.03.2021

(51) International Patent Classification (IPC):  A61B 1/06(2006.01) A61N 5/06(2006.01) A61B 1/267(2006.01) A61N 5/08(2006.01) (52) Cooperative Patent Classification (CPC): A61N 5/0603; A61N 2005/0604; A61N 2005/0608; A61N 2005/0609; A61N 2005/0611; A61N 2005/061; A61N 2005/0661; A61N 2005/0652; A61N 5/0624 (86) International application number: PCT/US2021/023354 (87) International publication number: WO 2021/189020 (23.09.2021 Gazette 2021/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 20.03.2020 US 202062992861 P 23.03.2020 US 202062993595 P 27.03.2020 US 202063000788 P 20.04.2020 US 202063012727 P 08.03.2021 US 202163158350 P (71) Applicant: Cedars-Sinai Medical Center Los Angeles, CA 90048 (US)

(72) Inventors: REZAIE, Ali Hollywood, California 90048 (US) PIMENTEL, Mark Los Angeles, California 90034 (US) MELMED, Gil Y. Los Angeles, California 90035 (US) MATHUR, Ruchi Los Angeles, California 90034 (US) LEITE, Gabriela Guimaraes Sousa Porter Ranch, California 91326 (US) DEGTYAREV, Konstantin River Edge, New Jersey 07661 (US) BISCHOFF, Larry Mountain Lakes, New Jersey 07046 (US) GANDHI, Kuldeep Parsippany, New Jersey 07054 (US) QUINN, Michael V. East Hanover, New Jersey 07936 (US) CRONENBERG, Richard Mahwah, New Jersey 07430 (US) (74) Representative: HGF  HGF Limited 1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)