(19)

(11)

EP 4 121 541 A2

(12)

(88) Date of publication A3: 28.10.2021 (43) Date of publication: 25.01.2023 Bulletin 2023/04 (21) Application number: 21772422.8 (22) Date of filing: 12.03.2021

(51) International Patent Classification (IPC):  C12N 15/70(2006.01) A61P 31/04(2006.01) C12N 15/74(2006.01) A61K 39/05(2006.01) C07K 14/34(2006.01) C12P 21/02(2006.01) (52) Cooperative Patent Classification (CPC): C12P 21/02; C12P 21/06; C12N 9/0051; C12Y 108/01007; C12Y 108/01008; C12Y 304/11018; C12N 9/485; C12N 15/70; C07K 14/34; C07K 14/33; C07K 14/005; C12N 2710/16222; C07K 14/5428; C07K 14/31 (86) International application number: PCT/US2021/022126 (87) International publication number: WO 2021/188379 (23.09.2021 Gazette 2021/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 16.03.2020 US 202016819775 16.03.2020 US 202062990083 P 24.02.2021 US 202163152954 P (71) Applicant: Fina Biosolutions LLC Rockville, MD 20850 (US)	(72) Inventors: CHANG, Min-Ju Gaithersburg, Maryland 20878 (US) OGANESYAN, Natalia Potomac, Maryland 20878 (US) LEES, Andrew Silver Spring, Maryland 20910 (US) (74) Representative: Forresters IP LLP  Skygarden Erika-Mann-Straße 11 80636 München 80636 München (DE)