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(11)

EP 4 125 947 A1

(12)

(43) Date of publication: 08.02.2023 Bulletin 2023/06 (21) Application number: 21776517.1 (22) Date of filing: 26.03.2021

(51) International Patent Classification (IPC):  A61K 35/12(1974.07) A61K 35/19(2015.01) C12M 1/26(1980.01) C12M 3/06(1990.01) A61K 35/14(1974.07) C12M 1/00(1980.01) C12M 1/34(1980.01) (52) Cooperative Patent Classification (CPC): A61P 37/06; C12N 5/0644; A61K 35/19; Y02A 50/30 (86) International application number: PCT/US2021/024442 (87) International publication number: WO 2021/195544 (30.09.2021 Gazette 2021/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 27.03.2020 US 202063000866 P 14.05.2020 US 202063024649 P 23.10.2020 US 202063104871 P 15.12.2020 US 202063125490 P 28.01.2021 US 202163142586 P (71) Applicant: Platelet Biogenesis, Inc. Watertown, Massachusetts 02472 (US)

(72) Inventors: HETT, Sunita R. Watertown, Massachusetts 02472 (US) WEISINGER, Karen Watertown, Massachusetts 02472 (US) PENG, Yang Watertown, Massachusetts 02472 (US) MCLAUGHLIN, Kyle P. Watertown, Massachusetts 02472 (US) PETERS, Christian G. Watertown, Massachusetts 02472 (US) ZUKAUSKAS, Andrew R. Watertown, Massachusetts 02472 (US) SMITH, Brenden W. Watertown, Massachusetts 02472 (US) GIANNINI, Silvia Watertown, Massachusetts 02472 (US) LEE, Po-Shun Watertown, Massachusetts 02472 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)