(19)
(11) EP 4 125 997 A1

(12)

(43) Date of publication:
08.02.2023 Bulletin 2023/06

(21) Application number: 21715260.2

(22) Date of filing: 30.03.2021
(51) International Patent Classification (IPC): 
A61K 38/17(1995.01)
A61K 38/42(1995.01)
 A61P 1/16(2000.01)
(52) Cooperative Patent Classification (CPC):
A61K 38/1767; A61P 1/16; A61K 38/42
(86) International application number:
PCT/EP2021/058229
(87) International publication number:
WO 2021/198216 (07.10.2021 Gazette 2021/40)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 31.03.2020 EP 20315083

(71) Applicants:
  • Institut National de la Santé et de la Recherche Médicale (INSERM)
    75013 Paris (FR)
  • Université de Rennes 1
    35000 Rennes (FR)
  • Chu De Rennes
    35000 Rennes (FR)
  • Hemarina
    29600 Morlaix (FR)

(72) Inventors:
  • LAGENTE, Vincent
    35033 RENNES Cedex 09 (FR)
  • GICQUEL, Thomas
    35033 RENNES Cedex 09 (FR)
  • LE DARE, Brendan
    35000 RENNES (FR)
  • DELPY, Eric
    29600 MORLAIX (FR)
  • ZAL, Franck
    29600 MORLAIX (FR)

(74) Representative: Lavoix 
2, place d'Estienne d'Orves
75441 Paris Cedex 09
75441 Paris Cedex 09 (FR)

   


(54) NEW METHOD TO TREAT THE HEPATOTOXICITY INDUCED BY AMANITINS