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(11)

EP 4 127 150 A1

(12)

(43) Date of publication: 08.02.2023 Bulletin 2023/06 (21) Application number: 21780536.5 (22) Date of filing: 31.03.2021

(51) International Patent Classification (IPC):  C12N 9/04(1980.01) C12Q 1/54(1980.01) C12Q 1/00(1980.01) (52) Cooperative Patent Classification (CPC): B01D 71/34; B01D 2325/48; B01D 67/0088; B01D 71/54; B01D 2323/39; B01D 67/0004; B01D 67/0079; B01D 71/024; B01D 2239/0631; B01D 2239/0442; B01D 2239/0645; B01D 2239/0478; B01D 2239/1216; B01D 2239/025; B01D 39/1692; A41D 13/1192; B01D 2239/0457; A62B 23/02 (86) International application number: PCT/US2021/025285 (87) International publication number: WO 2021/202820 (07.10.2021 Gazette 2021/40)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 31.03.2020 US 202063002435 P 20.11.2020 US 202063116799 P (71) Applicants: Matregenix, Inc. Irvine, CA 92617 (US) Soliman, Sherif Irvine, California 92617 (US)

(72) Inventors: GUO, Feng Irvine, California 92617 (US) SOLIMAN, Sherif Irvine, California 92617 (US) (74) Representative: Bajjon, Alexander et al Schlich 9 St. Catherine's Road Littlehampton, West Sussex BN17 5HS Littlehampton, West Sussex BN17 5HS (GB)