(19)

(11)

EP 4 127 209 A2

(12)

(88) Date of publication A3: 11.11.2021 (43) Date of publication: 08.02.2023 Bulletin 2023/06 (21) Application number: 21775064.5 (22) Date of filing: 24.03.2021

(51) International Patent Classification (IPC):  C12Q 1/68(1980.01) G01N 33/68(1980.01) A61K 31/335(1974.07) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07D 403/12; C07D 471/04; C07D 409/12; C07D 487/04; C07D 239/48 (86) International application number: PCT/US2021/023981 (87) International publication number: WO 2021/195279 (30.09.2021 Gazette 2021/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 24.03.2020 US 202062994259 P 20.01.2021 US 202163139394 P (71) Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE Denver, CO 80203 (US)	(72) Inventors: LABARBERA, Daniel V. Aurora, Colorado 80016 (US) ABBOTT, Joshua M. Aurora, Colorado 80247 (US) ZHOU, Qiong Aurora, Colorado 80016 (US) ABRAHAM, Adedoyin D. Aurora, Colorado 80012 (US) ESQUER, Hector Aurora, Colorado 80045 (US) PRIGARO, Brett Joseph Broomfield, Colorado 80023 (US) (74) Representative: FRKelly  27 Clyde Road Dublin D04 F838 Dublin D04 F838 (IE)