(19)
(11) EP 4 129 292 A8

(12) CORRECTED EUROPEAN PATENT APPLICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 A1)

(48) Corrigendum issued on:
22.03.2023 Bulletin 2023/12

(43) Date of publication:
08.02.2023 Bulletin 2023/06

(21) Application number: 21000212.7

(22) Date of filing: 04.08.2021
(51) International Patent Classification (IPC): 
A61K 31/506(2006.01)
A61K 9/70(2006.01)
A61Q 3/02(2006.01)
 A61K 8/87(2006.01)
A61P 31/10(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 31/506; A61P 31/10; A61Q 3/02; A61K 9/7015; A61K 8/87; A61K 8/49; A61K 8/34; A61K 8/36; A61K 8/37
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(71) Applicants:
  • OnychoPharm GmbH
    13507 Berlin (DE)
  • epinamics GmbH
    14195 Berlin (DE)

(72) Inventors:
  • Brembeck, Felix
    10785 Berlin (DE)
  • Baasner, Bernd
    51467 Bergisch-Gladbach (DE)
  • Fugmann, Burkhard
    40878 Ratingen (DE)
  • Thiede, Hans-Michael
    14773 Potsdam (DE)
  • Kehr, Wolfgang
    14195 Berlin (DE)

   


(54) FORMULATION FOR SUBSTITUTED 2-AMINOTHIAZOLES IN THE TREATMENT OF FUNGAL AND FUNGAL-BACTERIAL INFECTIONS OF THE NAIL


(57) A formulation for substituted 2-aminothiazoles in the prophylaxis and treatment of fungal and fungal-bacterial infections of the nail (onychomycosis) is disclosed. These formulations are particularly suitable for the topical application onto a nail. After evaporation of the solvent a thin polymer layer is formed on the nail from which the substituted 2-aminothiazole diffuses into the nail and the nail bed. A particularly effective substituted 2-aminothiazole is abafungin. The substituted 2-aminothiazoles are not only fungicidal, but also sporicidal and anti-bacterial. This is a novel approach to efficiently treat onychomycosis and to avoid frequent relapses of the infection.