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EP 4 132 530 A1

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(43) Date of publication: 15.02.2023 Bulletin 2023/07 (21) Application number: 21719267.3 (22) Date of filing: 07.04.2021

(51) International Patent Classification (IPC):  A61K 31/506(2000.01) A61K 45/06(1974.07) A61K 31/519(2000.01) A61P 35/00(2000.01) (52) Cooperative Patent Classification (CPC): A61K 31/506; A61K 31/519; A61K 45/06; A61P 35/00   C-Sets: A61K 31/506, A61K 2300/00; A61K 31/519, A61K 2300/00; (86) International application number: PCT/IB2021/052894 (87) International publication number: WO 2021/205363 (14.10.2021 Gazette 2021/41)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 08.04.2020 US 202063007329 P 23.03.2021 US 202163165049 P (71) Applicants: Pfizer Inc. New York, NY 10017 (US) The Regents of the University of Colorado, a body corporate Denver, CO 80203 (US)

(72) Inventors: ARORA, Mansi Framingham, Massachusetts 01701 (US) DANN, Stephen George Poway, California 92064 (US) GOODMAN MILLER, Nicole Lee Poway, California 92064 (US) SPENCER, Sabrina Boulder, Colorado 80302 (US) VANARSDALE, Todd Lee San Diego, California 92121 (US) (74) Representative: Berggren Oy  P.O. Box 16 Eteläinen Rautatiekatu 10A 00101 Helsinki 00101 Helsinki (FI)