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EP 4 135 724 A1

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(43) Date of publication: 22.02.2023 Bulletin 2023/08 (21) Application number: 20722966.7 (22) Date of filing: 15.04.2020

(51) International Patent Classification (IPC):  A61K 35/17(2015.01) C12N 5/0783(2010.01) (52) Cooperative Patent Classification (CPC): C12N 5/0636; A61K 35/14; A61K 35/15; A61K 35/18; A61K 35/19   C-Sets: A61K 35/19, A61K 2300/00; A61K 35/18, A61K 2300/00; A61K 35/15, A61K 2300/00; (86) International application number: PCT/US2020/028192 (87) International publication number: WO 2021/211104 (21.10.2021 Gazette 2021/42)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (71) Applicant: Amgen Inc. Thousand Oaks, CA 91320-1799 (US)	(72) Inventors: LIU, Yijun Thousand Oaks, California 91320-1799 (US) HENCKELS, Kathryn A. Thousand Oaks, California 91320-1799 (US) ARBELAEZ, Carlos Thousand Oaks, California 91320-1799 (US) (74) Representative: Dörries, Hans Ulrich  df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München 80333 München (DE)