(19)

(11)

EP 4 135 852 A1

(12)

(43) Date of publication: 22.02.2023 Bulletin 2023/08 (21) Application number: 21788164.8 (22) Date of filing: 13.04.2021

(51) International Patent Classification (IPC):  A61P 37/00(2006.01) A61P 37/06(2006.01) A61K 39/00(2006.01) C12N 15/861(2006.01) (52) Cooperative Patent Classification (CPC): A61P 37/00; A61P 37/06; A61K 39/0008; A61K 2039/53; A61K 2039/577; C12N 2750/14143; C12N 2830/008; A61K 48/0058; A01K 2207/10; A01K 2227/105; A01K 2267/0368; A01K 2267/0356 (86) International application number: PCT/US2021/027167 (87) International publication number: WO 2021/211640 (21.10.2021 Gazette 2021/42)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 14.04.2020 US 202063010028 P (71) Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED Gainesville, FL 32611-5500 (US)	(72) Inventor: HOFFMAN, Brad, E. Gainesville, FL 32606 (US) (74) Representative: Potter Clarkson  Chapel Quarter Chapel Bar Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)