(19)
(11) EP 4 138 823 A1

(12)

(43) Date of publication:
01.03.2023 Bulletin 2023/09

(21) Application number: 21724013.4

(22) Date of filing: 23.04.2021
(51) International Patent Classification (IPC): 
A61K 31/4196(2006.01)
A61P 35/00(2006.01)
 A61K 45/06(2006.01)
A61K 39/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 39/001102; A61K 39/39541; A61K 45/06; A61K 2039/505; A61P 35/00; C07K 16/2818; C07K 16/2863; C07K 16/2866; G01N 33/5748; G01N 33/57496; G01N 2800/52; A61K 31/502
 
C-Sets:
  1. A61K 39/39541, A61K 2300/00;
  2. A61K 31/502, A61K 2300/00;
(86) International application number:
PCT/GB2021/050999
(87) International publication number:
WO 2021/214492 (28.10.2021 Gazette 2021/43)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30) Priority: 24.04.2020 GB 202006072
27.11.2020 US 202063118764 P
01.02.2021 US 202163144296 P
23.02.2021 US 202163152654 P

(71) Applicants:
  • BerGenBio ASA
    5867 Bergen (NO)
  • The Board of Regents of the University of Texas System
    Austin, Texas 78701 (US)

(72) Inventors:
  • LORENS, James
    5009 Bergen (NO)
  • MICKLEM, David
    5009 Bergen (NO)
  • LI, Huiyu
    Dallas, TX 75235 (US)
  • LIU, Zhida
    Taiyuan City Shanxi Province, 030032 (CN)
  • MINNA, John
    Dallas, TX 75390-9141 (US)
  • BREKKEN, Rolf
    Dallas, TX 75229 (US)

(74) Representative: Mewburn Ellis LLP 
Aurora Building Counterslip
Bristol BS1 6BX
Bristol BS1 6BX (GB)

   


(54) METHOD OF SELECTING PATIENTS FOR TREATMENT WITH A COMBINATION OF AN AXL INHIBITOR AND AN IMMUNE CHECKPOINT MODULATOR