(19)

(11)

EP 4 138 904 A1

(12)

(43) Date of publication: 01.03.2023 Bulletin 2023/09 (21) Application number: 21792557.7 (22) Date of filing: 20.04.2021

(51) International Patent Classification (IPC):  A61K 39/215(2006.01) C07K 14/14(2006.01) A61P 31/14(2006.01) (52) Cooperative Patent Classification (CPC): A61P 31/14; A61K 39/12; C12N 2770/20034; C12N 2720/12334; A61K 2039/5256; A61K 2039/5254; C07K 14/005; C12N 15/86; C12N 2770/20022; C12N 2720/12343 (86) International application number: PCT/US2021/028195 (87) International publication number: WO 2021/216575 (28.10.2021 Gazette 2021/43)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 20.04.2020 US 202063012870 P (71) Applicant: The Trustees of Indiana University Bloomington, IN 47405 (US)	(72) Inventors: PATTON, John Thomas Bloomington, Indiana 47401 (US) PHILIP, Asha Ann Bloomington, IN 47403 (US) (74) Representative: V.O.  P.O. Box 87930 2508 DH Den Haag 2508 DH Den Haag (NL)