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EP 4 139 679 A1

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(43) Date of publication: 01.03.2023 Bulletin 2023/09 (21) Application number: 21818392.9 (22) Date of filing: 02.06.2021

(51) International Patent Classification (IPC):  G01N 33/50(2006.01) G01N 27/00(2006.01) G01N 30/58(2006.01) B01L 3/00(2006.01) G01N 30/00(2006.01) G01N 30/74(2006.01) (52) Cooperative Patent Classification (CPC): G01N 33/544; G01N 33/54373; B01L 3/502707; B01L 3/502715; B01L 3/502761; B01L 2200/027; B01L 2300/069; B01L 2300/0816; B01L 2300/0877; B01L 2300/0887; B01L 2300/161; B01L 2400/086; C12M 23/16 (86) International application number: PCT/US2021/035512 (87) International publication number: WO 2021/247750 (09.12.2021 Gazette 2021/49)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 02.06.2020 US 202063033699 P (71) Applicants: University of Utah Research Foundation Salt Lake City, UT 84108 (US) Leber, Moritz M. Salt Lake City, Utah 84108 (US)

(72) Inventors: REICHE, Christopher F. Salt Lake City, Utah 84103 (US) SOLZBACHER, Florian Salt Lake City, Utah 84112 (US) LAURENTIUS, Lars B. Cottonwood Heights, Utah 84121 (US) LEU, Hsuan-Yu Salt Lake City, Utah 84108 (US) BOROOMAND, Saeed Salt Lake City, Utah 84112 (US) KOERNER, Julia 30453 Hannover (DE) LEBER, Moritz M. Salt Lake City, Utah 84108 (US) (74) Representative: Hepworth Browne  15 St. Pauls Street Leeds LS1 2JG Leeds LS1 2JG (GB)