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EP 4 142 702 A1

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(43) Date of publication: 08.03.2023 Bulletin 2023/10 (21) Application number: 21731597.7 (22) Date of filing: 02.05.2021

(51) International Patent Classification (IPC):  A61K 31/13(2006.01) A61K 31/357(2006.01) A61K 31/40(2006.01) A61K 31/4427(2006.01) A61K 31/506(2006.01) A61K 31/64(2006.01) A61K 31/7072(2006.01) A61K 31/708(2006.01) A61K 31/155(2006.01) A61K 31/375(2006.01) A61K 31/433(2006.01) A61K 31/495(2006.01) A61K 31/517(2006.01) A61K 31/704(2006.01) A61K 31/7076(2006.01) (52) Cooperative Patent Classification (CPC): A61K 45/06; A61K 31/708; A61K 31/13; A61K 31/64; A61K 31/506; A61K 31/40; A61K 31/4427; A61K 31/375; A61K 31/704; A61K 31/495; A61K 31/7076; A61K 31/7072; A61K 31/517; A61K 31/357; A61K 31/433; A61K 31/155; A61P 31/14 (86) International application number: PCT/IL2021/050501 (87) International publication number: WO 2021/220284 (04.11.2021 Gazette 2021/44)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 01.05.2020 US 202063018598 P 24.11.2020 US 202063117619 P (71) Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. 91390 Jerusalem (IL)

(72) Inventors: ARKIN, Isaiah 9083600 Har Adar (IL) SINGH TOMAR, Prabhat Pratap 9767101 Jerusalem (IL) KRUGLIAK, Miriam 9063100 Beit El (IL) (74) Representative: Boult Wade Tennant LLP  Salisbury Square House 8 Salisbury Square London EC4Y 8AP London EC4Y 8AP (GB)