(19)

(11)

EP 4 143 303 A1

(12)

(43) Date of publication: 08.03.2023 Bulletin 2023/10 (21) Application number: 21797771.9 (22) Date of filing: 29.04.2021

(51) International Patent Classification (IPC):  C12N 5/0797(2010.01) A61P 25/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 25/00; C12N 5/0622; C12N 2502/081; C12N 2501/599; C12N 2501/25 (86) International application number: PCT/US2021/029806 (87) International publication number: WO 2021/222507 (04.11.2021 Gazette 2021/44)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 01.05.2020 US 202063018939 P (71) Applicant: The Children's Medical Center Corporation Boston, Massachusetts 02115 (US)	(72) Inventors: HE, Zhigang Boston, Massachusetts 02115 (US) WANG, Jing Boston, Massachusetts 02115 (US) HE, Xuelian Boston, Massachusetts 02115 (US) (74) Representative: Impact Intellectual Property LLP  1 Sans Walk London EC1R 0LT London EC1R 0LT (GB)