(19)

(11)

EP 4 149 630 A2

(12)

(88) Date of publication A3: 16.12.2021 (43) Date of publication: 22.03.2023 Bulletin 2023/12 (21) Application number: 21727522.1 (22) Date of filing: 12.05.2021

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) A61K 38/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C12Y 603/02019; A61K 38/00; C07K 2319/01 (86) International application number: PCT/GB2021/051138 (87) International publication number: WO 2021/229221 (18.11.2021 Gazette 2021/46)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 12.05.2020 GB 202006974 (71) Applicant: Oxford University Innovation Limited Oxford, OX2 0JB (GB)	(72) Inventors: RABBITTS, Terrence London SW7 3RP (GB) BERY, Nicolas 37150 Dierre (FR) (74) Representative: HGF  HGF Limited 1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB)