(19)

(11)

EP 4 150 112 A1

(12)

(43) Date of publication: 22.03.2023 Bulletin 2023/12 (21) Application number: 21740608.1 (22) Date of filing: 17.05.2021

(51) International Patent Classification (IPC):  C12Q 1/6806(2018.01) (52) Cooperative Patent Classification (CPC): C12Q 1/6806   C-Sets: C12Q 1/6806, C12Q 2527/125, C12Q 2563/185; (86) International application number: PCT/IB2021/054206 (87) International publication number: WO 2021/229549 (18.11.2021 Gazette 2021/46)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 15.05.2020 PT 2020116392 (71) Applicant: Universidade de Aveiro 3810-193 Aveiro (PT)	(72) Inventors: RISO DA COSTA COELHO, Francisco José 3800-438 Aveiro (PT) MARCIAL GOMES, Newton Carlos 3830-766 Gafanha Da Nazaré (PT) DOS SANTOS FERREIRA, Marina Rafaela 4520-603 São João De Ver (PT) MARTINS VIEIRA, Fabiana Yamasaki 3810-172 Aveiro (PT) (74) Representative: Patentree  Edificio Net Rua de Salazares, 842 4149-002 Porto 4149-002 Porto (PT)