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(11)

EP 4 153 615 A1

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(43) Date of publication: 29.03.2023 Bulletin 2023/13 (21) Application number: 21808174.3 (22) Date of filing: 19.05.2021

(51) International Patent Classification (IPC):  C07K 14/705(2006.01) A61P 29/00(2006.01) A61K 38/00(2006.01) C07K 19/00(2006.01) G01N 33/53(2006.01) (52) Cooperative Patent Classification (CPC): A61P 29/00; C07K 14/70503; C07K 2319/31; C07K 17/06; A61K 51/088; A61K 47/68; A61K 47/62; A61K 47/6907; A61K 47/543; G01N 33/6893; G01N 2800/065; G01N 2333/70546; G01N 2800/52 (86) International application number: PCT/IL2021/050576 (87) International publication number: WO 2021/234699 (25.11.2021 Gazette 2021/47)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 19.05.2020 US 202063026793 P 31.12.2020 US 202063132510 P (71) Applicant: Ramot at Tel-Aviv University Ltd. Tel-Aviv 6139201 (IL)	(72) Inventors: DAMMES, Niels 6139201 Tel Aviv (IL) PEER, Dan 6139201 Tel Aviv (IL) (74) Representative: Isarpatent  Patent- und Rechtsanwälte Barth Charles Hassa Peckmann & Partner mbB Friedrichstrasse 31 80801 München 80801 München (DE)