(19)

(11)

EP 4 157 300 A2

(12)

(88) Date of publication A3: 03.03.2022 (43) Date of publication: 05.04.2023 Bulletin 2023/14 (21) Application number: 21813023.5 (22) Date of filing: 01.06.2021

(51) International Patent Classification (IPC):  A61K 35/76(2006.01) A61K 39/13(2006.01) C12N 15/10(2006.01) A61K 39/12(2006.01) C12N 15/09(2006.01) C12Q 1/68(2006.01) (52) Cooperative Patent Classification (CPC): C12Q 1/6806; C12Q 1/701; C12N 15/1096   C-Sets: C12Q 1/6806, C12Q 2521/107, C12Q 2525/191, C12Q 2531/113, C12Q 2535/122, C12Q 2563/179; C12N 15/1096, C12Q 2521/107, C12Q 2563/179; (86) International application number: PCT/US2021/035240 (87) International publication number: WO 2021/243333 (02.12.2021 Gazette 2021/48)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 29.05.2020 US 202063032120 P 15.12.2020 US 202063125501 P (71) Applicant: BioHSV Holdings, Inc. Huntsville, AL 35806 (US)	(72) Inventors: MOORE, David Troy Huntsville, Alabama 35806 (US) VARLEY, Katherine Elena Salt Lake City, Utah 84013 (US) (74) Representative: Greaves Brewster LLP  Copa House Station Road Cheddar, Somerset BS27 3AH Cheddar, Somerset BS27 3AH (GB)