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EP 4 161 581 A1

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(43) Date of publication: 12.04.2023 Bulletin 2023/15 (21) Application number: 21740294.0 (22) Date of filing: 03.06.2021

(51) International Patent Classification (IPC):  A61K 47/68(2017.01) C07K 16/30(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 47/6811; A61K 47/6851; A61P 35/00; A61K 47/6849; A61K 47/6879; A61K 47/6889; C07K 2317/92; C07K 2317/622; C07K 16/3092; C07K 16/2863; C07K 2317/31; C07K 2317/24; C07K 2317/55; C07K 2317/64; C07K 2317/34; C07K 2317/33; C07K 2317/77 (86) International application number: PCT/US2021/035600 (87) International publication number: WO 2021/247798 (09.12.2021 Gazette 2021/49)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 03.06.2020 US 202063034296 P (71) Applicant: Merck Patent GmbH 64293 Darmstadt (DE)

(72) Inventors: KNUEHL, Christine 64293 Darmstadt (DE) TOLEIKIS, Lars 64293 Darmstadt (DE) AMENDT, Christiane 64293 Darmstadt (DE) DOERNER, Achim 64293 Darmstadt (DE) LI, Xiaofan South San Francisco, CA 94080 (US) STAFFORD, Ryan South San Francisco, CA 94080 (US) HENNINGSEN, Robert South San Francisco, CA 94080 (US) ZHOU, Sihong South San Francisco, CA 94080 (US) YAM, Alice South San Francisco, CA 94080 (US)