METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING MYOPIA WITH S-METHYL-L-THIOCITRULLINE, A SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE (NNOS) INHIBITOR, AND DERIVATIVES THEREOF - Patent 4164685

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EP 4 164 685 A1

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(43)	Date of publication:
	19.04.2023 Bulletin 2023/16

(21)	Application number: 21821067.2

(22)	Date of filing: 10.06.2021

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International Patent Classification (IPC):

A61K 39/145^(2006.01)
A61K 39/00^(2006.01)

A61K 39/39^(2006.01)

(52)	Cooperative Patent Classification (CPC):
	A61K 31/198

(86)	International application number:
	PCT/US2021/036741

(87)	International publication number:
	WO 2021/252719 (16.12.2021 Gazette 2021/50)

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
	Designated Extension States:
	BA ME
	Designated Validation States:
	KH MA MD TN

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Priority:

11.06.2020 US 202063037920 P

(71)	Applicant: The Trustees of Columbia University in the City of New York
	New York, NY 10027 (US)

(72)	Inventors:
	TKATCHENKO, Andrei V. Rye, New York 10580 (US) TKATCHENKO, Tatiana V. Rye, New York 10580 (US)

(74)	Representative: FRKelly
	27 Clyde Road Dublin D04 F838 Dublin D04 F838 (IE)

(54)	METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING MYOPIA WITH S-METHYL-L-THIOCITRULLINE, A SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE (NNOS) INHIBITOR, AND DERIVATIVES THEREOF