(19)

(11)

EP 4 165 051 A1

(12)

(43) Date of publication: 19.04.2023 Bulletin 2023/16 (21) Application number: 21743321.8 (22) Date of filing: 10.06.2021

(51) International Patent Classification (IPC):  C07D 519/00(2006.01) A61K 31/5025(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 519/00; A61P 35/00; Y02A 50/30 (86) International application number: PCT/US2021/036839 (87) International publication number: WO 2021/252781 (16.12.2021 Gazette 2021/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 12.06.2020 US 202063038410 P (71) Applicant: Incyte Corporation Wilmington, DE 19803 (US)	(72) Inventors: PAN, Jun Media, Pennsylvania 19063 (US) BAI, Yu Claymont, Delaware 19703 (US) WU, Liangxing Wilmington, Delaware 19808 (US) YAO, Wenqing Chadds Ford, Pennsylvania 19317 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)