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(11)

EP 4 165 190 A1

(12)

(43) Date of publication: 19.04.2023 Bulletin 2023/16 (21) Application number: 21821421.1 (22) Date of filing: 11.06.2021

(51) International Patent Classification (IPC):  C12N 15/63(2006.01) C07K 14/725(2006.01) C12N 15/90(2006.01) C07K 16/28(2006.01) (52) Cooperative Patent Classification (CPC): C12N 2310/20; C12N 15/907; C07K 14/7051 (86) International application number: PCT/US2021/037012 (87) International publication number: WO 2021/252898 (16.12.2021 Gazette 2021/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 12.06.2020 US 202063038516 P 15.03.2021 US 202163161283 P (71) Applicant: PACT Pharma, Inc. South San Francisco, CA 94080 (US)

(72) Inventors: MENDE, Ines South San Francisco, CA 94080 (US) TUNUGUNTLA, Ramya H. South San Francisco, CA 94080 (US) TZIZIK-SWANSON, Nathaniel R. South San Francisco, CA 94080 (US) YEDINAK, Gregory S. South San Francisco, CA 94080 (US) MANDL-CASHMAN, Stefanie South San Francisco, CA 94080 (US) JACOBY, Kyle South San Francisco, CA 94080 (US) GIEDLIN, Martin South San Francisco, CA 94080 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)