(19)

(11)

EP 4 167 958 A1

(12)

(43) Date of publication: 26.04.2023 Bulletin 2023/17 (21) Application number: 21742249.2 (22) Date of filing: 21.06.2021

(51) International Patent Classification (IPC):  A61K 9/00(2006.01) A61K 9/51(2006.01) A61K 38/28(2006.01) A61P 3/10(2006.01) A61K 9/16(2006.01) A61K 31/436(2006.01) A61K 39/00(2006.01) A61P 37/06(2006.01) (52) Cooperative Patent Classification (CPC): A61K 9/5153; A61K 9/1647; A61K 38/28; A61K 31/436; A61P 3/10; A61P 37/06; A61K 2039/577; A61K 39/0008; A61K 2039/55511   C-Sets: A61K 31/436, A61K 2300/00; A61K 38/28, A61K 2300/00; (86) International application number: PCT/US2021/038209 (87) International publication number: WO 2021/258042 (23.12.2021 Gazette 2021/51)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 19.06.2020 US 202016907055 (71) Applicant: Yale University New Haven, CT 06510 (US)	(72) Inventors: FAHMY, Tarek M. Middlefield, Connecticut 06455 (US) LEE, Jung Seok New Haven, Connecticut 06511 (US) KIM, Dongin Glastonbury, Connecticut 06033 (US) (74) Representative: Potter Clarkson  Chapel Quarter Mount Street Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)